Vendor source
Reviewed 2 Oct 2026
Completeness Comprehensive (83%)
BoneXpert analyses an X-ray of a child's hand automatically, without any interference from a human. The main result is the Greulich Pyle bone age - TW2/3 bone ages can also be given. BoneXpert also reports the bone age standard deviation score. The X-ray can be of a left or a right hand and the hand can assume any rotation in the image plane. The analysis is automatically rejected, if it cannot be done reliably, e.g. if there is too much image postprocessing. Finally, the Bone Heath Index is determined from the cortical thicknesses in the metacarpals.
Supported by 23 papers


General Information
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Regulatory Information
Pathway:
MDD
Class:
Class I
Verified by Health AI Register
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Evidence & Research
Peer-Reviewed Papers
Quantifying human variability in pediatric bone age assessment: a multi-institutional multi-reader study and benchmark for AI evaluation
Pediatric Radiology · Sep 2026
Automatic bone age assessment for adult height prediction in children with congenital adrenal hyperplasia
Journal of Pediatric Endocrinology and Metabolism · May 2026
Comparative study of the performance of two versions of the same AI tool for pediatric skeletal maturation assessment
European Radiology · Jan 2026
Bone Health Index (BoneXpert) and parameters of peripheral quantitative computed tomography indicate overall adequate bone health in adolescents with chronic endocrine diseases at time of transition
PLOS One · Dec 2025
Hand X-ray metrics for assessing bone health and fracture risk in Duchenne muscular dystrophy: a cross-sectional study
European Journal of Pediatrics · Nov 2025
Automated bone age calculation is an independent predictor of vertebral fracture burden in Duchenne muscular dystrophy
Osteoporosis International · Oct 2025
Comparative analysis of an automated bone age tool with manual assessment in a multiethnic Southeast Asian paediatric cohort in Singapore
Pediatric Radiology · Aug 2025
Cortical bone status and its determinants in pediatric Klinefelter syndrome
Endocrine Connections · Aug 2025
Comparison of bone age assessment using manual Greulich and Pyle method versus automated BoneXpert method in South African children
South African Journal of Radiology · Apr 2025
Automatic Bone Age Determination in Adult Height Prediction for Girls with Early Variants Puberty and Precoccious Puberty
Journal of Clinical Research in Pediatric Endocrinology · Feb 2025
A comparison of two artificial intelligence-based methods for assessing bone age in Turkish children: BoneXpert and VUNO Med-Bone Age
Diagnostic and Interventional Radiology · Sep 2024
Performance of two different artificial intelligence (AI) methods for assessing carpal bone age compared to the standard Greulich and Pyle method
La radiologia medica · Aug 2024
Comparison of Commercial AI Software Performance for Radiograph Lung Nodule Detection and Bone Age Prediction
Radiology · Jan 2024
Accuracy and self-validation of automated bone age determination
Scientific Reports · Apr 2022
Autonomous artificial intelligence in pediatric radiology: the use and perception of BoneXpert for bone age assessment
Pediatric Radiology · Feb 2022
Automated determination of bone age from hand X-rays at the end of puberty and its applicability for age estimation
International Journal of Legal Medicine · Oct 2016
Validation of automatic bone age determination in children with congenital adrenal hyperplasia
Pediatric Radiology · Oct 2013
Validation of automatic bone age rating in children with precocious and early puberty
Journal of Pediatric Endocrinology and Metabolism · Nov 2011
Validation and Reference Values of Automated Bone Age Determination for Four Ethnicities
Academic Radiology · Aug 2010
A paediatric bone index derived by automated radiogrammetry
Osteoporosis International · Nov 2009
Prediction of Adult Height Based on Automated Determination of Bone Age
The Journal of Clinical Endocrinology & Metabolism · Nov 2009
An Automated Method for Determination of Bone Age
The Journal of Clinical Endocrinology & Metabolism · Apr 2009
Clinical application of automated Greulich-Pyle bone age determination in children with short stature
Pediatric Radiology · Mar 2009
Technical Specifications
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Source: Vendor | First published: Sep 4, 2024 | Last updated: Oct 2, 2026