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Artificial intelligence reading digital mammogram: enhancing detection and differentiation of suspicious microcalcifications
British Journal of Radiology (BJR), 2025
Abstract
Objectives
To investigate the impact of artificial intelligence (AI) on enhancing the sensitivity of digital mammograms in the detection and specification of grouped microcalcifications.
Methods
The study is a retrospective analysis of grouped microcalcifications for 447 patients. Grouped microcalcifications detected were correlated with AI, which was applied to the initial mammograms. AI provided a heat map, demarcation, and quantitative evaluation for abnormalities according to the degree of suspicion of malignancy. Histopathology was the standard for confirmation of malignancy.
Results
AI showed a high correlation percentage of 67.5% between the red colour of the colour hue bar and malignant microcalcifications (P-value <.001). The scoring of probable cancer was suggested (ie, more than 50% abnormality scoring) in 39.5% of true cancer lesions. The diagnostic performance of mammography for grouped microcalcifications revealed a sensitivity of 94.7% and a negative predictive value of 82.1%. False negatives were only 12 out of 228 that proved malignant calcifications. The agreement of cancer probability between standard mammograms and examinations read by AI presented a Kappa value of -0.094 and a P-value of <.001.
Conclusions
The used AI system enhanced the sensitivity of mammograms in detecting suspicious microcalcifications, yet an expert human reader is required for proper specification.
Advances in knowledge
Grouped calcifications could be early breast cancer on a mammogram. The morphology and distribution are correlated with the nature of breast diseases. AI is a potential decision support for the detection and classification of grouped microcalcifications and thus positively affects the control of breast cancer.
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