Company: Spimed-AI Product: CorEx
Coronary artery disease detection using deep learning and ultrahigh-resolution photon-counting coronary CT angiography
Diagnostic and Interventional Imaging, 2024
Abstract
Purpose
The purpose of this study was to evaluate the diagnostic performance of automated deep learning in the detection of coronary artery disease (CAD) on photon-counting coronary CT angiography (PC-CCTA).
Materials and methods
Consecutive patients with suspected CAD who underwent PC-CCTA between January 2022 and December 2023 were included in this retrospective, single-center study. Non-ultra-high resolution (UHR) PC-CCTA images were analyzed by artificial intelligence using two deep learning models (CorEx, Spimed-AI), and compared to human expert reader assessment using UHR PC-CCTA images. Diagnostic performance for global CAD assessment (at least one significant stenosis ≥ 50 %) was estimated at patient and vessel levels.
Results
A total of 140 patients (96 men, 44 women) with a median age of 60 years (first quartile, 51; third quartile, 68) were evaluated. Significant CAD on UHR PC-CCTA was present in 36/140 patients (25.7 %). The sensitivity, specificity, accuracy, positive predictive value), and negative predictive value of deep learning-based CAD were 97.2 %, 81.7 %, 85.7 %, 64.8 %, and 98.9 %, respectively, at the patient level and 96.6 %, 86.7 %, 88.1 %, 53.8 %, and 99.4 %, respectively, at the vessel level. The area under the receiver operating characteristic curve was 0.90 (95 % CI: 0.83-0.94) at the patient level and 0.92 (95 % CI: 0.89-0.94) at the vessel level.
Conclusion
Automated deep learning shows remarkable performance for the diagnosis of significant CAD on non-UHR PC-CCTA images. AI pre-reading may be of supportive value to the human reader in daily clinical practice to target and validate coronary artery stenosis using UHR PC-CCTA.
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